[HTML][HTML] Olfactory stimulation regulates the birth of neurons that express specific odorant receptors
In mammals, olfactory sensory neurons (OSNs) are born throughout life, ostensibly solely to
replace damaged OSNs. During differentiation, each OSN precursor" chooses," out of
hundreds of possibilities, a single odorant receptor (OR) gene, which defines the identity of
the mature OSN. The relative neurogenesis rates of the hundreds of distinct OSN" subtypes"
are thought to be constant, as they are determined by a stochastic process in which each OR
is chosen with a fixed probability. Here, using histological, single-cell, and targeted affinity …
replace damaged OSNs. During differentiation, each OSN precursor" chooses," out of
hundreds of possibilities, a single odorant receptor (OR) gene, which defines the identity of
the mature OSN. The relative neurogenesis rates of the hundreds of distinct OSN" subtypes"
are thought to be constant, as they are determined by a stochastic process in which each OR
is chosen with a fixed probability. Here, using histological, single-cell, and targeted affinity …
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