On-target versus off-target effects of drugs inhibiting the replication of SARS-CoV-2
The current epidemic of coronavirus disease-19 (COVID-19) caused by severe acute
respiratory syndrome coronavirus-2 (SARS-CoV-2) calls for the development of inhibitors of
viral replication. Here, we performed a bioinformatic analysis of published and purported
SARS-CoV-2 antivirals including imatinib mesylate that we found to suppress SARS-CoV-2
replication on Vero E6 cells and that, according to the published literature on other
coronaviruses is likely to act on-target, as a tyrosine kinase inhibitor. We identified a cluster …
respiratory syndrome coronavirus-2 (SARS-CoV-2) calls for the development of inhibitors of
viral replication. Here, we performed a bioinformatic analysis of published and purported
SARS-CoV-2 antivirals including imatinib mesylate that we found to suppress SARS-CoV-2
replication on Vero E6 cells and that, according to the published literature on other
coronaviruses is likely to act on-target, as a tyrosine kinase inhibitor. We identified a cluster …
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