The article features cyclobenzaprine extended-release (ER) as an effective medication for neck pain, low back pain and acute muscle spasm accounting for 190 billion dollars annually in direct US-based medical costs. As a once-daily dose, cyclobenzaprine ER uses the Diffucaps technology that leads to an increased efficacy and early systematic delivery of the active drug. A common adverse effect to the drug is somnolence. Nonpharmacologic treatment for neck and back pains include heat application, acupuncture and massage therapy.