Highly efficient one‐pot synthesis of a series of substituted 3‐methylene‐isoindolinones (3 a–
x), bis (isoindolinone) ethanes (4 a–d) and 3‐hydroxy‐isoindolinones (6 a–h) derivatives is
portrayed from easily accessible starting materials such as 2‐cyanobenzaldehydes (1 a–h)
and different aryl/heteroaryl methyl ketones (2 a–k). The structure of Z‐isomer of 3‐
methylene‐isoindolinone 3 x was confirmed by single crystal X‐ray analysis. The reaction
mechanism studies by control experiments and using O18‐labelled water revealed that the …

Highly efficient one-pot synthesis of a series of substituted 3-methylene-isoindolinones(3a-
x), bis (isoindolinone) ethanes (4a-d) and 3-hydroxy-isoindolinones (6a-h) derivatives is
portrayed from easily accessible starting materials such as 2-cyanobenzaldehydes (1a-h)
and different aryl/heteroaryl methyl ketones (2a-k). The structure of Z-isomer of 3-methylene-
isoindolinone 3x was confirmed by a single crystal X-ray analysis. The reaction mechanism
studies by control experiments and using O18-labelled water revealed that the reaction was …