Open randomized multicenter study to evaluate safety and efficacy of low molecular weight sulfated dextran in islet transplantation
B von Zur-Mühlen, T Lundgren, L Bayman… - …, 2019 - journals.lww.com
B von Zur-Mühlen, T Lundgren, L Bayman, C Berne, N Bridges, T Eggerman, A Foss…
Transplantation, 2019•journals.lww.comBackground. When transplanted human pancreatic islets are exposed to blood during
intraportal infusion, an innate immune response is triggered. This instant blood-mediated
inflammatory reaction (IBMIR) activates the coagulation and complement cascades and
leads to the destruction of 25% of all transplanted islets within minutes, contributing to the
need, in most patients, for islets from more than 1 donor. Low molecular dextran sulfate
(LMW-DS) has been shown in experimental settings to inhibit IBMIR. Methods.
intraportal infusion, an innate immune response is triggered. This instant blood-mediated
inflammatory reaction (IBMIR) activates the coagulation and complement cascades and
leads to the destruction of 25% of all transplanted islets within minutes, contributing to the
need, in most patients, for islets from more than 1 donor. Low molecular dextran sulfate
(LMW-DS) has been shown in experimental settings to inhibit IBMIR. Methods.
Abstract
Background.
When transplanted human pancreatic islets are exposed to blood during intraportal infusion, an innate immune response is triggered. This instant blood-mediated inflammatory reaction (IBMIR) activates the coagulation and complement cascades and leads to the destruction of 25% of all transplanted islets within minutes, contributing to the need, in most patients, for islets from more than 1 donor. Low molecular dextran sulfate (LMW-DS) has been shown in experimental settings to inhibit IBMIR.
Methods.
Lippincott Williams & Wilkins以上显示的是最相近的搜索结果。 查看全部搜索结果