Objectives: Trauma ICU patients may require high and/or prolonged doses of opioids and/or
benzodiazepines as part of their treatment. These medications may contribute to drug
physical dependence, a response manifested by withdrawal syndrome. We aimed to identify
risk factors, symptoms, and clinical variables associated with probable withdrawal
syndrome. Design: Prospective exploratory observational study. Setting: Trauma ICU in
large medical center in Puerto Rico. Participants: Fifty patients who received opioids and/or …