Suspended Microchannels Resonators (SMRs) are a subfield of microfluidic and micro-electro-mechanical systems. The key concept of this field is to combine a microfluidic channel and a resonant cantilever to measure some properties or components of the liquid, as its density, passing through the microchannel. The effective mass of the cantilever will change according to the liquid and this change will affect the resonant frequency of the cantilever. There is also the possibility to change the resonant frequency of the SMR while changing the stiffness of the SMR. This change can occurs when a bio-entity pass on the SMR’s bracket. In the 90s, the research of SMR focused on the manufacture of densitometers for the chemical industry and agribusiness [2]. These SMRs were mostly fabricated in glass or monocristallin silicon using several etching process. The growing research around biotechnology, especially around label-free techniques, has pushed researchers to introduce SMRs as a new technique for bio-molecular sensing in 2003 [3]. The fabrication of the SMRs was still based on etching of silicon. As a result, the manufacturing methods around the channels and the detection sensor have multiplied. We can mention the methods via silicon self-assembly [4] or creating SMRs in silicon nitride. The disadvantage of these techniques lies in the large number of manufacturing steps in a clean room. Dozens of steps are needed [5]. Other methods based on microprocessing by femtolaser followed by KOH etching allow a reduction of manufacturing steps, but the dimensions of the channels remain large (around 30 micrometers for the thickness of the walls) which lowers the sensitivity of the SMRs [6]. In addition, SMRs fabricated in glass, silicon or silicon nitride remain with an high stiffness which can be annoying for the stiffness measurement of bio-entity such as cancer cells.