Optimization of microwave-assisted extraction of flavonoids and antioxidants from Vernonia amygdalina leaf using response surface methodology
In this study, the microwave-assisted extraction (MAE) variables were optimized using a face-
centered central composite design of response surface methodology for optimal recoveries
of total flavonoid content (TFC) and antioxidant capacities (DPPH and ABTS) of Vernonia
amygdalina leaf extract. The independent variables were irradiation time (5–15 min),
microwave power level (400–600 W), temperature (90–110° C), and feed-to-solvent ratio
(0.08–0.13 g/ml). The ANOVA results showed that TFC, DPPH and ABTS radical scavenging …
centered central composite design of response surface methodology for optimal recoveries
of total flavonoid content (TFC) and antioxidant capacities (DPPH and ABTS) of Vernonia
amygdalina leaf extract. The independent variables were irradiation time (5–15 min),
microwave power level (400–600 W), temperature (90–110° C), and feed-to-solvent ratio
(0.08–0.13 g/ml). The ANOVA results showed that TFC, DPPH and ABTS radical scavenging …
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