Orexin-A/hypocretin-1 controls the vta-nac mesolimbic pathway via endocannabinoid-mediated disinhibition of dopaminergic neurons in obese mice
L Tunisi, L D'Angelo, AC Fernández-Rilo… - Frontiers in Synaptic …, 2021 - frontiersin.org
Disinhibition of orexin-A/hypocretin-1 (OX-A) release occurs to several output areas of the
lateral hypothalamus (LH) in the brain of leptin knockout obese ob/ob mice. In this study, we
have investigated whether a similar increase of OX-A release occurs to the ventral tegmental
area (VTA), an orexinergic LH output area with functional effects on dopaminergic signaling
at the mesolimbic circuit. By confocal and correlative light and electron microscopy (CLEM)
morphological studies coupled to molecular, biochemical, and pharmacological …
lateral hypothalamus (LH) in the brain of leptin knockout obese ob/ob mice. In this study, we
have investigated whether a similar increase of OX-A release occurs to the ventral tegmental
area (VTA), an orexinergic LH output area with functional effects on dopaminergic signaling
at the mesolimbic circuit. By confocal and correlative light and electron microscopy (CLEM)
morphological studies coupled to molecular, biochemical, and pharmacological …
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