Organotypic 3D Cell-Architecture Impacts the Expression Pattern of miRNAs–mRNAs Network in Breast Cancer SKBR3 Cells
MÁ Gastélum-López, M Aguilar-Medina… - Non-coding RNA, 2023 - mdpi.com
Background. Currently, most of the research on breast cancer has been carried out in
conventional two-dimensional (2D) cell cultures due to its practical benefits, however, the
three-dimensional (3D) cell culture is becoming the model of choice in cancer research
because it allows cell–cell and cell–extracellular matrix (ECM) interactions, mimicking the
native microenvironment of tumors in vivo. Methods. In this work, we evaluated the effect of
3D cell organization on the expression pattern of miRNAs (by Small-RNAseq) and mRNAs …
conventional two-dimensional (2D) cell cultures due to its practical benefits, however, the
three-dimensional (3D) cell culture is becoming the model of choice in cancer research
because it allows cell–cell and cell–extracellular matrix (ECM) interactions, mimicking the
native microenvironment of tumors in vivo. Methods. In this work, we evaluated the effect of
3D cell organization on the expression pattern of miRNAs (by Small-RNAseq) and mRNAs …
Organotypic 3D Cell-Architecture Impacts the Expression Pattern of miRNAs-mRNAs Network in Breast Cancer SKBR3 Cells
GL MdlÁ, M Aguilar-Medina, J López-Gutiérrez… - 2023 - europepmc.org
Background: Currently, most of the research in breast cancer has been carried out in
conventional two-dimensional (2D) cell culture due to its practical benefits, however, the
three-dimensional (3D) cell culture is becoming the model of choice in cancer research
because it allows cell-cell and cell-extracellular matrix (ECM) interactions, mimicking the
native microenvironment of tumors in vivo. Methods. in this work, we evaluated the effect of
3D cell organization on the expression pattern of miRNAs (by Small-RNAseq) and mRNAs …
conventional two-dimensional (2D) cell culture due to its practical benefits, however, the
three-dimensional (3D) cell culture is becoming the model of choice in cancer research
because it allows cell-cell and cell-extracellular matrix (ECM) interactions, mimicking the
native microenvironment of tumors in vivo. Methods. in this work, we evaluated the effect of
3D cell organization on the expression pattern of miRNAs (by Small-RNAseq) and mRNAs …
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