Female mice have a greater capacity for exercising in the heat than male mice, reaching
greater power output and longer times of heat exposure before succumbing to exertional
heat stroke (EHS). Differences in body mass, size, or testosterone do not explain these
distinct sex responses. Whether the ovaries could account for the superior exercise capacity
in the heat in females remains unknown. Here, we determined the influence of ovariectomy
(OVX) on exercise capacity in the heat, thermoregulation, intestinal damage, and heat shock …

Female mice have a greater capacity for exercising in the heat than male mice, reaching 26
greater power output and longer times of heat exposure before succumbing to EHS. 27
Differences in body mass, size, or testosterone do not explain these distinct sex responses.
28 Whether the ovaries could account for the superior exercise capacity in the heat in
females 29 remains unknown. Here, we determined the influence of ovariectomy (OVX) on
exercise 30 capacity in the heat, thermoregulation, intestinal damage, and heat shock …