It has been proposed that the Xenopus homeobox gene, XlHbox8, is involved in
endodermal differentiation during pancreatic and duodenal development (Wright, CVE,
Schnegelsberg, P. and De Robertis, EM (1988). Development 105, 787–794). To test this
hypothesis directly, gene targeting was used to make two different null mutations in the
mouse XlHbox8 homolog, pdx-1. In the first, the second pdx-1 exon, including the
homeobox, was replaced by a neomycin resistance cassette. In the second, a lacZ reporter …

PDX-1 is required for pancreatic outgrowth and differentiation of rostral duodenum | CiNii
Research … PDX-1 is required for pancreatic outgrowth and differentiation of rostral duodenum …