Marbofloxacin is a fluoroquinolone antibiotic and highly effective treatment for respiratory
diseases. Here we aimed to evaluate the ex vivo activity of marbofloxacin against
Streptococcus suis in pig serum, as well as the optimal dosages scheme for avoiding the
fluoroquinolone resistance development. A single dose of 8 mg/kg body weight (bw) was
administrated orally to healthy pigs and serum samples were collected during the next 72 h.
Serum marbofloxacin content was determined by high-performance liquid chromatography …