[HTML][HTML] PKCα is required for inflammation-induced trafficking of extrasynaptic AMPA receptors in tonically firing lamina II dorsal horn neurons during the maintenance …
O Kopach, V Viatchenko-Karpinski, FE Atianjoh… - The Journal of …, 2013 - Elsevier
Persistent inflammation promotes internalization of synaptic GluR2-containing, Ca2+-
impermeable AMPA receptors (AMPARs) and insertion of GluR1-containing, Ca2+-
permeable AMPARs at extrasynaptic sites in dorsal horn neurons. Previously we have
shown that internalization of synaptic GluR2-containing AMPARs requires activation of
spinal cord protein kinase C alpha (PKCα), but molecular mechanisms that underlie altered
trafficking of extrasynaptic AMPARs are unclear. Here, using antisense (AS) …
impermeable AMPA receptors (AMPARs) and insertion of GluR1-containing, Ca2+-
permeable AMPARs at extrasynaptic sites in dorsal horn neurons. Previously we have
shown that internalization of synaptic GluR2-containing AMPARs requires activation of
spinal cord protein kinase C alpha (PKCα), but molecular mechanisms that underlie altered
trafficking of extrasynaptic AMPARs are unclear. Here, using antisense (AS) …
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