The host endolysosomal compartment is often manipulated by intracellular bacterial
pathogens. Salmonella (Salmonella enterica serovar Typhimurium) secrete numerous
effector proteins, including SifA, through a specialized type III secretion system to hijack the
host endosomal system and generate the Salmonella-containing vacuole (SCV). To form
this replicative niche, Salmonella targets the Rab7 GTPase to recruit host membranes
through largely unknown mechanisms. We show that Pleckstrin homology domain …

The host endolysosomal compartment is often manipulated by intracellular bacterial
pathogens. Salmonella (Salmonella enterica serovar Typhimurium) secrete numerous
effector proteins, including SifA, through a specialized type III secretion system to hijack the
host endosomal system and generate the Salmonella-containing vacuole (SCV). To form
this replicative niche, Salmonella targets the Rab7 GTPase to recruit host membranes
through largely unknown mechanisms. We show that Pleckstrin homology domain …