… , PROREPAIR-B is the first prospective study designed to assess the prevalence and impact
of gDDR mutations in … It is also likely the last prospective report on the survival and treatment …

… Background: Germline mutations in DNA repair genes … Prospective multicentre observational
study of newly diagnosed mCRPC patients with unknown germline mutation status at study …

… the discrepancies identified among different retrospective analyses, prospective studies are
now needed evaluating the impact of germline DNA repair mutations in advanced prostate …

… [12], where carriers of DNA repair mutations were, on average, diagnosed only ~1 year
younger than non-carriers. Taken together, these findings raise the question as to whether …

… Methods: PROREPAIR-B study is a prospective multicenter observational cohort study.
Blood samples and clinical data have been collected prospectively in 38 centres across Spain. …

… The clinical importance of germline mutations in DNA repair … , the PROREPAIR-B study
found the outcomes of germline … treatment given in their mCRPC cohort. They identified BRCA2 …

… The prospective PROREPAIR-B study found that germline … germline testing for the subsets
of patients with prostate cancer who are more likely to have germline DNA repair mutations (…

… DNA Repair … Germ-Line Mutation … Prospective Studies …

… , one analyzed somatic mutations and two studies included both germline and somatic (…
This study included two DNA repair genes (BRCA1/2) in the definition of DDR mutations. …

… which could have a confounding effect on the outcomes. PROREPAIR-B 13 was the first
prospective study designed to evaluate the impact of germline DDR mutations on the outcome(s…