PVT1 lncRNA in lung cancer: A key player in tumorigenesis and therapeutic opportunities

MA Hakami, A Hazazi, FR Khan, O Abdulaziz… - … -Research and Practice, 2024 - Elsevier
The lncRNA PVT1 has emerged as a pivotal component in the intricate landscape of cancer
pathogenesis, particularly in lung cancer. PVT1, situated in the 8q24 chromosomal region,
has garnered attention for its aberrant expression patterns in lung cancer, correlating with
tumor progression, metastasis, and poor prognosis. Numerous studies have unveiled the
diverse mechanisms PVT1 contributes to lung cancer pathogenesis. It modulates critical
pathways, such as cell proliferation, apoptosis evasion, angiogenesis, and epithelial …
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