Palladium-catalyzed, multicomponent approach to β-lactams via aryl halide carbonylation
GM Torres, M De La Higuera Macias… - The Journal of …, 2016 - ACS Publications
A palladium-catalyzed multicomponent method for the synthesis of β-lactams from imines,
aryl halides, and CO has been developed. This transformation proceeds via two tandem
catalytic carbonylation reactions mediated by Pd (P t Bu3) 2 and provides a route to prepare
these products from five separate reagents. A diverse range of polysubstituted β-lactams can
be generated by systematic variation of the substrates. This methodology can also be
extended to the use of iodo-substituted imines to produce novel spirocyclic β-lactams in …
aryl halides, and CO has been developed. This transformation proceeds via two tandem
catalytic carbonylation reactions mediated by Pd (P t Bu3) 2 and provides a route to prepare
these products from five separate reagents. A diverse range of polysubstituted β-lactams can
be generated by systematic variation of the substrates. This methodology can also be
extended to the use of iodo-substituted imines to produce novel spirocyclic β-lactams in …
[引用][C] Palladium-Catalyzed, Multicomponent Approach to β-Lactams via Aryl Halide Carbonylation
Y Veeranna - 2016
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