Pan‐striatal reduction in the expression of the astrocytic dopamine transporter precedes the development of dorsolateral striatum dopamine‐dependent incentive …

T Hynes, M Fouyssac, M Puaud, D Joshi… - European Journal of …, 2024 - Wiley Online Library
The emergence of compulsive drug‐seeking habits, a hallmark feature of substance use
disorder, has been shown to be predicated on the engagement of dorsolateral striatal
control over behaviour. This process involves the dopamine‐dependent functional coupling
of the anterior dorsolateral striatum (aDLS) with the nucleus accumbens core, but the
mechanisms by which this coupling occurs have not been fully elucidated. The striatum is
tiled by a syncytium of astrocytes that express the dopamine transporter (DAT), the level of …

Pan-striatal reduction in the expression of the astrocytic dopamine transporter precedes the development of dorsolateral striatum dopamine-dependent incentive …

D Belin, T Hynes, M Fouyssac, M Puaud, D Joshi… - 2024 - repository.cam.ac.uk
The emergence of compulsive drug seeking habits, a hallmark feature of substance use
disorder, has been shown to be predicated on the engagement of dorsolateral striatal
control over behaviour. This process involves the dopamine-dependent functional coupling
of the anterior dorsolateral striatum (aDLS) with the nucleus accumbens core, but the
mechanisms by which this coupling occurs have not been fully elucidated. The striatum is
tiled by a syncytium of astrocytes that express the dopamine transporter (DAT), the level of …
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