Pancreatic acinar cells: effects of lanthanum ions on amylase release and calcium ion fluxes

DE Chandler, JA Williams - The Journal of Physiology, 1974 - ncbi.nlm.nih.gov
DE Chandler, JA Williams
The Journal of Physiology, 1974ncbi.nlm.nih.gov
… In the present study LaS+ has been used to evaluate further the role of plasma
membrane Ca2+ fluxes during stimulation of amylase release. Lanthanum is known to
inhibit Ca2+ fluxes across artificial membranes as well as the plasma membrane of heart
cells, smooth muscle and nerve (van Breeman & van Breeman, 1969; Weiss & Goodman,
1969; van Breeman & De Weer, 1970; Langer & Frank, 1972; van Breeman, Farinas,
Casteels, Gerba, Wuytack & Deth, 1973). In addition, it is thought to displace tightly bound …
Abstract
1. The effect of La 3+ on amylase release and Ca 2+ fluxes in mouse pancreatic fragments in vitro was studied.
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