Pandemrix-induced narcolepsy is associated with genes related to immunity and neuronal survival
P Hallberg, H Smedje, N Eriksson, H Kohnke… - …, 2019 - thelancet.com
Background The incidence of narcolepsy rose sharply after the swine influenza A (H1N1)
vaccination campaign with Pandemrix. Narcolepsy is an immune-related disorder with
excessive daytime sleepiness. The most frequent form is strongly associated with HLA-
DQB1* 06: 02, but only a minority of carriers develop narcolepsy. We aimed to identify
genetic markers that predispose to Pandemrix-induced narcolepsy. Methods We tested for
genome-wide and candidate gene associations in 42 narcolepsy cases and 4981 controls …
vaccination campaign with Pandemrix. Narcolepsy is an immune-related disorder with
excessive daytime sleepiness. The most frequent form is strongly associated with HLA-
DQB1* 06: 02, but only a minority of carriers develop narcolepsy. We aimed to identify
genetic markers that predispose to Pandemrix-induced narcolepsy. Methods We tested for
genome-wide and candidate gene associations in 42 narcolepsy cases and 4981 controls …