We consider a general inhomogeneous parabolic initial-boundary value problem for a -parabolic differential equation given in a finite multidimensional cylinder. We investigate the solvability of this problem in some generalized anisotropic Sobolev spaces. They are parametrized with a pair of positive numbers and and with a function that varies slowly at infinity. The function parameter characterizes subordinate regularity of distributions with respect to the power regularity given by the number parameters. We prove that the operator corresponding to this problem is an isomorphism on appropriate pairs of these spaces. As an application, we give a theorem on the local regularity of the generalized solution to the problem. We also obtain sharp sufficient conditions under which chosen generalized derivatives of the solution are continuous on a given set.