Particulate air pollutants, APOE alleles and their contributions to cognitive impairment in older women and to amyloidogenesis in experimental models
M Cacciottolo, X Wang, I Driscoll, N Woodward… - Translational …, 2017 - nature.com
Exposure to particulate matter (PM) in the ambient air and its interactions with APOE alleles
may contribute to the acceleration of brain aging and the pathogenesis of Alzheimer's
disease (AD). Neurodegenerative effects of particulate air pollutants were examined in a US-
wide cohort of older women from the Women's Health Initiative Memory Study (WHIMS) and
in experimental mouse models. Residing in places with fine PM exceeding EPA standards
increased the risks for global cognitive decline and all-cause dementia respectively by 81 …
may contribute to the acceleration of brain aging and the pathogenesis of Alzheimer's
disease (AD). Neurodegenerative effects of particulate air pollutants were examined in a US-
wide cohort of older women from the Women's Health Initiative Memory Study (WHIMS) and
in experimental mouse models. Residing in places with fine PM exceeding EPA standards
increased the risks for global cognitive decline and all-cause dementia respectively by 81 …
[引用][C] Particulate air pollutants, APOE alleles and their contributions to cognitive impairment in older women and to amyloidogenesis in experimental models. Transl …
M Cacciottolo, X Wang, I Driscoll, N Woodward… - Press.[Europe PMC free …, 2016
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