Synaptic activity-induced calcium ion (Ca 2+) influx and subsequent propagation of Ca 2+
into the nucleus is a major way in which synapses communicate with the nucleus to regulate
transcriptional programs that maintain activity-dependent survival and mediate memory
formation. Nuclear Ca 2+ shapes the transcriptome by regulating cAMP response element-
binding protein (CREB)-dependent transcription. Here we utilize Drosophila and induced
pluripotent stem cell (iPSC)-derived neurons from humans with Alzheimer's disease to study …

Synaptic activity-induced calcium (Ca 2+) influx and subsequent propagation into the
nucleus is a major way in which synapses communicate with the nucleus to regulate
transcriptional programs important for activity-dependent survival and memory formation.
Nuclear Ca 2+ shapes the transcriptome by regulating cyclic AMP (cAMP) response element-
binding protein (CREB). Here, we utilize a Drosophila model of tauopathy and induced
pluripotent stem cell (iPSC)-derived neurons from humans with Alzheimer's disease to study …