Pathogenicity genomic island-associated CrpP-like fluoroquinolone-modifying enzymes among Pseudomonas aeruginosa clinical isolates in Europe
JM Ortiz de la Rosa, P Nordmann… - Antimicrobial agents and …, 2020 - Am Soc Microbiol
Antimicrobial agents and chemotherapy, 2020•Am Soc Microbiol
Many transferable quinolone resistance mechanisms have been identified in Gram-negative
bacteria. The plasmid-encoded 65-amino-acid-long ciprofloxacin-modifying enzyme CrpP
was recently identified in Pseudomonas aeruginosa isolates. We analyzed a collection of
100 clonally unrelated and multidrug-resistant P. aeruginosa clinical isolates, among which
46 were positive for crpP-like genes, encoding five CrpP variants conferring variable levels
of reduced susceptibility to fluoroquinolones. These crpP-like genes were chromosomally …
bacteria. The plasmid-encoded 65-amino-acid-long ciprofloxacin-modifying enzyme CrpP
was recently identified in Pseudomonas aeruginosa isolates. We analyzed a collection of
100 clonally unrelated and multidrug-resistant P. aeruginosa clinical isolates, among which
46 were positive for crpP-like genes, encoding five CrpP variants conferring variable levels
of reduced susceptibility to fluoroquinolones. These crpP-like genes were chromosomally …
Abstract
Many transferable quinolone resistance mechanisms have been identified in Gram-negative bacteria. The plasmid-encoded 65-amino-acid-long ciprofloxacin-modifying enzyme CrpP was recently identified in Pseudomonas aeruginosa isolates. We analyzed a collection of 100 clonally unrelated and multidrug-resistant P. aeruginosa clinical isolates, among which 46 were positive for crpP-like genes, encoding five CrpP variants conferring variable levels of reduced susceptibility to fluoroquinolones. These crpP-like genes were chromosomally located as part of pathogenicity genomic islands.
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