Patient-derived monoclonal antibody neutralizes SARS-CoV-2 Omicron variants and confers full protection in monkeys

C Fenwick, P Turelli, D Ni, L Perez, K Lau… - Nature …, 2022 - nature.com
… Using a SARS-CoV-2 Omicron monkey challenge … ), confers complete prophylactic or
therapeutic protection. Although we could select for SARS-CoV-2 mutants escaping neutralization

[HTML][HTML] Protective non-neutralizing SARS-CoV-2 monoclonal antibodies

A Izadi, P Nordenfelt - Trends in immunology, 2024 - cell.com
… mAbs might target epitopes with less evolutionary selection pressure to mutate in SARS-CoV-2
variants compared with neutralizing mAbs; they can be Fc engineered … Show full caption …

P2G3 human monoclonal antibody neutralizes SARS-CoV-2 Omicron subvariants including BA. 4 and BA. 5 and Bebtelovimab escape mutants

P Turelli, C Fenwick, C Raclot, V Genet, G Pantaleo… - bioRxiv, 2022 - biorxiv.org
… , Omicron variants readily cause infections in individuals who have been either previously
infected with other SARS-CoV-2 variants or subjected to full … , conferred complete prophylactic …

IMM-BCP-01, a patient-derived anti–SARS-CoV-2 antibody cocktail, is active across variants of concern including Omicron BA. 1 and BA. 2

PA Nikitin, JM DiMuzio, JP Dowling, NB Patel… - Science …, 2022 - science.org
… library of patient-derived antiviral antibodies (21), we identified three monoclonal antibodies
(… 1C), the standalone IMM20184 antibody did not reach a complete neutralization of Omicron

Sotrovimab retains activity against SARS-CoV-2 Omicron variant BQ. 1.1 in a non-human primate model

C Hérate, R Marlin, F Touret, N Dereuddre-Bosquet… - Heliyon, 2023 - cell.com
Patient-derived monoclonal antibody neutralizes SARS-CoV-2 Omicron variants and confers
full … to prevent infection with SARS-CoV-2 (BQ.1.1 variant) following inoculation therefore it …

SARS-CoV-2 Omicron variant: Antibody evasion and cryo-EM structure of spike protein–ACE2 complex

D Mannar, JW Saville, X Zhu, SS Srivastava… - Science, 2022 - science.org
Omicron variant spike protein thus appear to confer broad … (B) Antibody binding footprints
for the monoclonal antibodies … IS and ACM provided the vaccine-induced patient-derived sera …

[HTML][HTML] Alarming antibody evasion properties of rising SARS-CoV-2 BQ and XBB subvariants

Q Wang, S Iketani, Z Li, L Liu, Y Guo, Y Huang… - Cell, 2023 - cell.com
… The BQ and XBB subvariants of SARS-CoV-2 Omicron are now rapidly expanding, possibly
Monoclonal antibodies capable of neutralizing the original Omicron variant were largely …

An elite broadly neutralizing antibody protects SARS-CoV-2 Omicron variant challenge

B Zhou, R Zhou, JFW Chan, M Luo, Q Peng, S Yuan… - bioRxiv, 2022 - biorxiv.org
… , Delta and Omicron variants conferred strong resistance to our … In these studies, patient-derived
S2E12 and vaccine-induced … of recombinant monoclonal antibodies for the SARS-CoV-2

A broadly neutralizing antibody protects Syrian hamsters against SARS-CoV-2 Omicron challenge

B Zhou, R Zhou, B Tang, JFW Chan, M Luo… - Nature …, 2022 - nature.com
conferred by circulating SARS-CoV-2 Omicron variants. The … In these studies, patient-derived
S2E12 and vaccine-induced … of recombinant monoclonal antibodies for the SARS-CoV-2

Rational in silico design identifies two mutations that restore UT28K SARS-CoV-2 monoclonal antibody activity against Omicron BA. 1

T Ozawa, Y Ikeda, L Chen, R Suzuki, A Hoshino… - Structure, 2024 - cell.com
… This approach circumvents the need for patient-derived neutralizing antibodies, and may …
binding activity and neutralizing activity against the Omicron BA.1 variant, we attempted to …