Patient-level pooled analysis of ultrasound renal denervation in the sham-controlled RADIANCE II, RADIANCE-HTN SOLO, and RADIANCE-HTN TRIO trials

AJ Kirtane, ASP Sharp, F Mahfoud, NDL Fisher… - JAMA …, 2023 - jamanetwork.com
Importance Ultrasound renal denervation (uRDN) was shown to lower blood pressure (BP)
in patients with uncontrolled hypertension (HTN). Establishing the magnitude and
consistency of the uRDN effect across the HTN spectrum is clinically important. Objective To
characterize the effectiveness and safety of uRDN vs a sham procedure from individual
patient-level pooled data across uRDN trials including either patients with mild to moderate
HTN on a background of no medications or with HTN resistant to standardized triple …
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