The burden of CKD is increasing rapidly worldwide and has become a major health issue. Majority of these patients die from CVD before progression to ESRD. Studies have shown that more than 50% of deaths in CKD patients are attributable to cardiovascular events. Lipid disorders are recognized risk factors for CVD and progression of renal diseases of varied aetiologies. There is paucity of information on the prevalence and pattern of lipids in CKD patients in our environment. It is for these reasons that this study was designed to determine serum lipid profile in dialysis naive CKD patients in UITH Ilorin, Nigeria. It was a descriptive cross sectional study that involved 120 CKD patients and sixty age and sex matched controls. The patients were recruited consecutively from nephrology clinics and adult medical wards, while controls were sourced from hospital staff and patient’s relatives. A venous blood sample was obtained from each patient and control after an overnight fast for lipid profile and creatinine determination. The lipid fractions were analysed using standard methods. Data was analyzed with SPSS version 16. P-value< 0.05 was considered significant. The mean+ SEM of total cholesterol (10.5+ 3.6 mmol/l) and triglyceride (3.4+ 1.5 mmol/l) in the patients were significantly higher when compared with that of the controls (5.4+ 0.5 mmol/l and 1.7+ 0.2 mmol/l) respectively, p< 0.05. The leading cause of CKD was chronic glomerulonephritis. Similarly, there were significant differences in HDL, LDL and LDL/HDL ratio between the study group and controls (0.6+ 0.4, 0.9+ 0.5, and 2.1+ 2.6 versus 1.2+ 0.3, 1.4+ 0.4 and 1.2+ 0.1 mmol/l) respectively, p< 0.05. However, both study group and control had total cholesterol as the most common dyslipidaemia. The study shows that dyslipidaemia is common among our dialysis naïve CKD patients, most especially in those with chronic glomerulonephritis. Our findings underscore the need for early assessment of these patients for lipid abnormalities as prompt treatment may prevent cardiovascular events and retard the progression of kidney disease.