[PDF][PDF] Increased apoptosis is linked to severe acute GVHD in patients with Fanconi anemia
M Romero, L Wang, P Ratajczak… - My parents, my … - repositorio.uniandes.edu.co
Fanconi anemia (FA) is a rare inherited disorder characterized by developmental defects,
genomic instability and progressive BM failure. 1 Hematopoietic allogeneic SCT (HSCT) can
restore normal hematopoiesis, 2–4 but these patients have an increased risk of grades 2–4
acute GVHD (aGVHD). 5 At the cellular level, the hallmarks of FA are hypersensitivity to DNA-
cross-linking agents and defective DNA repair. 6 Unrepaired DNA damage can further
activate p53-dependent7 and p53-independent8 signaling pathways of apoptosis.
genomic instability and progressive BM failure. 1 Hematopoietic allogeneic SCT (HSCT) can
restore normal hematopoiesis, 2–4 but these patients have an increased risk of grades 2–4
acute GVHD (aGVHD). 5 At the cellular level, the hallmarks of FA are hypersensitivity to DNA-
cross-linking agents and defective DNA repair. 6 Unrepaired DNA damage can further
activate p53-dependent7 and p53-independent8 signaling pathways of apoptosis.
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