Pellino 3b negatively regulates interleukin-1-induced TAK1-dependent NFκB activation
H Xiao, W Qian, K Staschke, Y Qian, G Cui… - Journal of Biological …, 2008 - ASBMB
IL-1 receptor-associated kinase (IRAK) is phosphorylated, ubiquitinated, and degraded
upon interleukin-1 (IL-1) stimulation. In this study, we showed that IRAK can be ubiquitinated
through both Lys-48-and Lys-63-linked polyubiquitin chains upon IL-1 induction. Pellino 3b
is the RING-like motif ubiquitin protein ligase that promotes the Lys-63-linked
polyubiquitination on IRAK. Pellino 3b-mediated Lys-63-linked IRAK polyubiquitination
competed with Lys-48-linked IRAK polyubiquitination for the same ubiquitination site, Lys …
upon interleukin-1 (IL-1) stimulation. In this study, we showed that IRAK can be ubiquitinated
through both Lys-48-and Lys-63-linked polyubiquitin chains upon IL-1 induction. Pellino 3b
is the RING-like motif ubiquitin protein ligase that promotes the Lys-63-linked
polyubiquitination on IRAK. Pellino 3b-mediated Lys-63-linked IRAK polyubiquitination
competed with Lys-48-linked IRAK polyubiquitination for the same ubiquitination site, Lys …
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