Perfluoroalkyl substances, sex hormones, and insulin-like growth factor-1 at 6–9 years of age: a cross-sectional analysis within the C8 Health Project
MJ Lopez-Espinosa, D Mondal… - Environmental …, 2016 - ehp.niehs.nih.gov
Background: Exposure to some perfluoroalkyl substances (PFAS), such as perfluorohexane
sulfonate (PFHxS), perfluorooctanoate (PFOA), perfluorooctane sulfonate (PFOS), and
perfluorononanoic acid (PFNA), may alter levels of sex hormones and insulin-like growth
factor-1 (IGF-1) in animals. Human studies on this topic are scarce, and none have been
conducted in young children. Objectives: We investigated the relationship between levels of
PFAS and estradiol, total testosterone, and IGF-1 in 2,292 children (6–9 years of age) from …
sulfonate (PFHxS), perfluorooctanoate (PFOA), perfluorooctane sulfonate (PFOS), and
perfluorononanoic acid (PFNA), may alter levels of sex hormones and insulin-like growth
factor-1 (IGF-1) in animals. Human studies on this topic are scarce, and none have been
conducted in young children. Objectives: We investigated the relationship between levels of
PFAS and estradiol, total testosterone, and IGF-1 in 2,292 children (6–9 years of age) from …
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