Peripheral‐specific y2 receptor knockdown protects mice from high‐fat diet‐induced obesity
Y Shi, S Lin, L Castillo, A Aljanova, RF Enriquez… - …, 2011 - Wiley Online Library
Y2 receptors, particularly those in the brain, have been implicated in neuropeptide Y (NPY)‐
mediated effects on energy homeostasis and bone mass. Recent evidence also indicates a
role for Y2 receptors in peripheral tissues in this process by promoting adipose tissue
accretion; however their effects on energy balance remain unclear. Here, we show that adult‐
onset conditional knockdown of Y2 receptors predominantly in peripheral tissues results in
protection against diet‐induced obesity accompanied by significantly reduced weight gain …
mediated effects on energy homeostasis and bone mass. Recent evidence also indicates a
role for Y2 receptors in peripheral tissues in this process by promoting adipose tissue
accretion; however their effects on energy balance remain unclear. Here, we show that adult‐
onset conditional knockdown of Y2 receptors predominantly in peripheral tissues results in
protection against diet‐induced obesity accompanied by significantly reduced weight gain …
Peripheral-specific Y2 receptor knockdown protects mice from high-fat diet-induced obesity.
SYC Shi YanChuan, LS Lin Shu, L Castillo, A Aljanova… - 2011 - cabidigitallibrary.org
Y2 receptors, particularly those in the brain, have been implicated in neuropeptide Y (NPY)-
mediated effects on energy homeostasis and bone mass. Recent evidence also indicates a
role for Y2 receptors in peripheral tissues in this process by promoting adipose tissue
accretion; however their effects on energy balance remain unclear. Here, we show that adult-
onset conditional knockdown of Y2 receptors predominantly in peripheral tissues results in
protection against diet-induced obesity accompanied by significantly reduced weight gain …
mediated effects on energy homeostasis and bone mass. Recent evidence also indicates a
role for Y2 receptors in peripheral tissues in this process by promoting adipose tissue
accretion; however their effects on energy balance remain unclear. Here, we show that adult-
onset conditional knockdown of Y2 receptors predominantly in peripheral tissues results in
protection against diet-induced obesity accompanied by significantly reduced weight gain …
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