[HTML][HTML] Persistence of an intact HIV reservoir in phenotypically naive T cells
Despite the efficacy of antiretroviral therapy (ART), HIV persists in a latent form and remains
a hurdle to eradication. CD4+ T lymphocytes harbor the majority of the HIV reservoir, but the
role of individual subsets remains unclear. CD4+ T cells were sorted into central,
transitional, effector memory, and naive T cells. We measured HIV DNA and performed
proviral sequencing of more than 1900 proviruses in 2 subjects at 2 and 9 years after ART
initiation to estimate the contribution of each subset to the reservoir. Although our study was …
a hurdle to eradication. CD4+ T lymphocytes harbor the majority of the HIV reservoir, but the
role of individual subsets remains unclear. CD4+ T cells were sorted into central,
transitional, effector memory, and naive T cells. We measured HIV DNA and performed
proviral sequencing of more than 1900 proviruses in 2 subjects at 2 and 9 years after ART
initiation to estimate the contribution of each subset to the reservoir. Although our study was …
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