Persisters—as elusive as ever

N Kaldalu, V Hauryliuk, T Tenson - Applied microbiology and …, 2016 - Springer
… In accepting the PaSH hypothesis and that we cannot switch off persister formation
pharmaceutically, how should persister research and the development of anti-persister therapy …

Persistent persister misperceptions

JS Kim, TK Wood - Frontiers in microbiology, 2016 - frontiersin.org
… , and the bulk of their data indicated persister cells are inactive. Paradoxically, the same …
, that persister cells are metabolically inactive as they write, “we used Persister-FACSeq on a …

[HTML][HTML] Combatting persister cells: The daunting task in post-antibiotics era

Y Zhou, H Liao, L Pei, Y Pu - Cell insight, 2023 - Elsevier
… redundant mechanisms of persister formation as well as methods of studying persister cells.
… approach for anti-persister therapy. That is, to force a persister into a deeper dormancy state …

Multidrug tolerance of biofilms and persister cells

K Lewis - Bacterial biofilms, 2008 - Springer
… ing this elusive problem is picking up. Formidable obstacles remain, due to difficulty in isolating
sufficient amounts of persister cells, the apparent redundancy of persister genes, and the …

Alarmones as bacterial persistence factor

Р Сидоров, А Ткаченко - Вестник Пермского университета. Серия …, 2023 - press.psu.ru
… a distinct subpopulation known as "persisters" within a bacterial population. Despite being
genetically identical to the regular cells, persisters possess the ability to endure antibiotic …

Single-cell imaging and characterization of Escherichia coli persister cells to ofloxacin in exponential cultures

F Goormaghtigh, L Van Melderen - Science advances, 2019 - science.org
… On the contrary to the prevailing hypothesis, we observed that persister cells are not
necessarily slow growers and that both persister and ofloxacin-sensitive cells endure comparable …

A pursuit of Staphylococcus aureus continues: a role of persister cells

JO Chang, RE Lee, W Lee - Archives of Pharmacal Research, 2020 - Springer
… is called persister cells. There is a mounting clinical evidence that these persister cells …
aureus persister cells is unavailable. This review focuses on drawing out a mechanistic map …

Combatting persister cells with substituted indoles

S Song, TK Wood - Frontiers in Microbiology, 2020 - frontiersin.org
persister cells. Hence, in this review, along with a summary of recent results related to
persister … substituted indoles to combat the persister cells of both pathogens and non-pathogens. …

Prophages and growth dynamics confound experimental results with antibiotic-tolerant persister cells

A Harms, C Fino, MA Sørensen, S Semsey, K Gerdes - MBio, 2017 - Am Soc Microbiol
persister cells. In this study, we unraveled how typical antibiotic killing assays often fail to
capture the biology of persisters … us to follow the dynamics of persister cells through all growth …

[HTML][HTML] Epigenetic memories: the hidden drivers of bacterial persistence?

L Riber, LH Hansen - Trends in microbiology, 2021 - cell.com
… Intriguingly, persister formation occurs as a phenotypic phenomenon in a subpopulation of
genetically identical cells. Here, persisters are formed by stochastic mechanisms relying on …