Scholars continue to call for research-informed treatment approaches for transgender clients. The existing literature directs therapists to learn about unique issues facing transgender individuals and to provide affirming therapy for transgender clients. We offer a person-centered approach to treatment for transgender individuals that integrates current scholarship with person-centered theory and offers specific interventions for use with transgender clients. These theoretical applications and interventions are offered for both interpersonal and intrapersonal work with clients. Following our analysis, we offer future areas of emphasis for treatment and research.