Personality traits are differentially associated with patterns of reward and novelty processing in the human substantia nigra/ventral tegmental area
BACKGROUND: The long-standing observation that the novelty-seeking personality trait is a
predictor of drug use and other reinforcable risky behaviors raises the question as to how
novelty and reward processing functionally interact in mesolimbic dopaminergic circuitry and
how this interaction is modulated by the novelty-seeking personality trait. METHODS:
Functional magnetic resonance imaging (fMRI) hemodynamic responses to novelty and
reward (monetary incentive) from the substantia nigra/ventral tegmental area (SN/VTA), the …
predictor of drug use and other reinforcable risky behaviors raises the question as to how
novelty and reward processing functionally interact in mesolimbic dopaminergic circuitry and
how this interaction is modulated by the novelty-seeking personality trait. METHODS:
Functional magnetic resonance imaging (fMRI) hemodynamic responses to novelty and
reward (monetary incentive) from the substantia nigra/ventral tegmental area (SN/VTA), the …
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