PharmVar GeneFocus: SLCO1B1

LB Ramsey, L Gong, S Lee, JB Wagner… - Clinical …, 2023 - Wiley Online Library
… until it was incorporated into PharmVar. As testing for SLCO1B1 is implemented in clinical
care, it … We summarize PharmVar's efforts to systematically catalog SLCO1B1 allelic variation, …

The frequency of SLCO1B1 c. 388A> G and SLCO1B1 c. 521T> C polymorphisms in the Croatian population

E Nedeljković - 2024 - repository.biotech.uniri.hr
… (23) Additionally, templates for reporting the genotype and phenotype frequencies of the
SLCO1B1 allele can be found on the PharmVar SLCO1B1 gene page under "Other Documents" …

[HTML][HTML] Simvastatin Therapy and SLCO1B1 Genotype

M Kane - Medical Genetics Summaries [Internet], 2024 - ncbi.nlm.nih.gov
… Of the 44 star alleles defined by PharmVar, only 13 SLCO1B1 star alleles have … SLCO1B1*1
and *37 alleles are classified as normal function, while multiple alleles such as SLCO1B1*5, …

SLCO1B1 Genetic Variation Influence on Atorvastatin Systemic Exposure in Pediatric Hypercholesterolemia

JB Wagner, S Abdel-Rahman, G Raghuveer… - Genes, 2024 - mdpi.com
… a posteriori to test additional variants in SLCO1B1 and variants of other genes that influence
… made manually for SLCO1B1, CYP3A4 and CYP3A5 based on PharmVar allele definitions …

Effects of SLCO1B1 Genetic Variant on Metabolite Profile in Participants on Simvastatin Treatment

L Fernandes Silva, R Ravi, J Vangipurapu, A Oravilahti… - Metabolites, 2022 - mdpi.com
… Our study is to first to show that SLCO1B1 rs4149056 variant … Additionally, we investigated
the effects of SLCO1B1 … metabolites significantly associated with SLCO1B1 rs4149056-C in …

The reduced function allele SLCO1B1 c. 521T> C is of no practical relevance for the renal graft function over the first post-transplant year in patients treated with …

SN Škegro, L Penezić, L Šimičević… - Pharmacogenetics …, 2024 - journals.lww.com
Objective It is unclear whether renal transplant recipients treated with mycophenolic acid (MPA)
who carry the reduced-function allele at polymorphism SLCO1B1 c. 521T> C differ from …

Impact of genetic variants in the solute carrier (SLC) genes encoding drug uptake transporters on the response to anticancer chemotherapy

JJG Marin, MA Serrano, E Herraez… - Cancer Drug …, 2024 - pmc.ncbi.nlm.nih.gov
… transport have been described for the SLCO1B1 gene [45] . … SLCO1B1 is one of the
critical genes involved in the … However, the most critical clinical annotations on SLCO1B1

Associations between four polymorphisms of the SLCO1B1 and effectiveness of the statins: a meta-analysis

HH Nguyen, CTT Nguyen, TNP Mai… - Pharmacogenetics and …, 2023 - journals.lww.com
… of the solute carrier anion transporter family 1B1 (SLCO1B1) gene, which encodes a transporter
… The current meta-analysis hence aimed to reveal the association of various SLCO1B1

SLCO1B1 Exome Sequencing and Statin Treatment Response in 64,000 UK Biobank Patients

D Türkmen, J Bowden, JAH Masoli, D Melzer… - International Journal of …, 2024 - mdpi.com
… We studied common and rare SLCO1B1 variants in up to 64,000 patients from UK Biobank …
Both SLCO1B1*5 alone and the SLCO1B1*15 haplotype increased LDL during treatment (…

[HTML][HTML] PharmVar: a Global resource and repository for pharmacogene variation

A Gaedigk, ST Casey, M Whirl-Carrillo… - Clinical …, 2021 - ncbi.nlm.nih.gov
… in detail in the PharmVar GeneFocus series of review articles … In addition, PharmVar is
introducing SLCO1B1, an important … SLCO1B1 experts have collected and reviewed published …