Pharmacological FMRI: measuring opioid effects on the BOLD response to hypercapnia
KTS Pattinson, R Rogers, SD Mayhew… - Journal of Cerebral …, 2007 - journals.sagepub.com
Opioid binding to the cerebral blood vessels may affect vascular responsiveness and hence
confound interpretation of blood oxygen level-dependent (BOLD) responses, which are
usually interpreted as neuronal in origin. Opioid binding varies in different brain regions. It is
unclear whether opioids alter neurovascular coupling, or whether their effects are purely
neuronal. This study used BOLD functional magnetic resonance imaging (FMRI) to
investigate the effect of a μ-opioid agonist remifentanil, on cerebrovascular CO2 reactivity …
confound interpretation of blood oxygen level-dependent (BOLD) responses, which are
usually interpreted as neuronal in origin. Opioid binding varies in different brain regions. It is
unclear whether opioids alter neurovascular coupling, or whether their effects are purely
neuronal. This study used BOLD functional magnetic resonance imaging (FMRI) to
investigate the effect of a μ-opioid agonist remifentanil, on cerebrovascular CO2 reactivity …