Pharmacological inhibition of DNMT1 restores macrophage autophagy and M2 polarization in Western diet–induced nonalcoholic fatty liver disease
Nonalcoholic fatty liver disease (NAFLD) is associated with an increased ratio of classically
activated M1 macrophages/Kupffer cells to alternatively activated M2 macrophages, which
plays an imperative role in the development and progression of NAFLD. However, little is
known about the precise mechanism behind macrophage polarization shift. Here, we
provide evidence regarding the relationship between the polarization shift in Kupffer cells
and autophagy resulting from lipid exposure. High-fat and high-fructose diet …
activated M1 macrophages/Kupffer cells to alternatively activated M2 macrophages, which
plays an imperative role in the development and progression of NAFLD. However, little is
known about the precise mechanism behind macrophage polarization shift. Here, we
provide evidence regarding the relationship between the polarization shift in Kupffer cells
and autophagy resulting from lipid exposure. High-fat and high-fructose diet …
以上显示的是最相近的搜索结果。 查看全部搜索结果