Pharmacological preconditioning with sildenafil: basic mechanisms and clinical implications
The phosphodiesterase type-5 (PDE5) inhibitor, sildenafil, is the first drug developed for
treatment of erectile dysfunction in patients. Experimental data in animals show that
sildenafil has a preconditioning-like cardioprotective effect against ischemia/reperfusion
injury in the intact heart. Mechanistic studies suggest that sildenafil exerts cardioprotection
through NO generated from eNOS/iNOS, activation of protein kinase C/ERK signaling and
opening of mitochondrial ATP-sensitive potassium channels. Additional studies show that …
treatment of erectile dysfunction in patients. Experimental data in animals show that
sildenafil has a preconditioning-like cardioprotective effect against ischemia/reperfusion
injury in the intact heart. Mechanistic studies suggest that sildenafil exerts cardioprotection
through NO generated from eNOS/iNOS, activation of protein kinase C/ERK signaling and
opening of mitochondrial ATP-sensitive potassium channels. Additional studies show that …
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