Phase equilibria of l–Valine/l–Leucine solid solutions
M Sadeghi, V Tenberg, S Münzberg, H Lorenz… - Journal of Molecular …, 2021 - Elsevier
M Sadeghi, V Tenberg, S Münzberg, H Lorenz, A Seidel-Morgenstern
Journal of Molecular Liquids, 2021•ElsevierModeling and experimental determination of Solid Liquid Equilibria (SLE) and the related
phase diagrams are challenging in the presence of solid solutions. In this work, the ternary
phase diagram of l–valine/l–leucine in water is measured and theoretically modelled at
298.15 K. The two similar molecules, l–valine and l–leucine form solid solutions as
confirmed by Powder X-Ray Diffraction (PXRD) experiments. In addition, the concentrations
of both equilibrated phases are determined using High Performance Liquid …
phase diagrams are challenging in the presence of solid solutions. In this work, the ternary
phase diagram of l–valine/l–leucine in water is measured and theoretically modelled at
298.15 K. The two similar molecules, l–valine and l–leucine form solid solutions as
confirmed by Powder X-Ray Diffraction (PXRD) experiments. In addition, the concentrations
of both equilibrated phases are determined using High Performance Liquid …
Abstract
Modeling and experimental determination of Solid Liquid Equilibria (SLE) and the related phase diagrams are challenging in the presence of solid solutions. In this work, the ternary phase diagram of l–valine/l–leucine in water is measured and theoretically modelled at 298.15 K. The two similar molecules, l–valine and l–leucine form solid solutions as confirmed by Powder X-Ray Diffraction (PXRD) experiments. In addition, the concentrations of both equilibrated phases are determined using High Performance Liquid Chromatography (HPLC). Nonidealities are described using Perturbed Chain-Statistical Associating Fluid Theory (PC-SAFT) and Non-Random Two-Liquid (NRTL) models for the liquid and solid phases, respectively. The models work well to describe the solubility curve, except some extreme points. Finally, a graphical separation method based on the Lippmann plot is derived and its potential use will be expanded for the separation of organic compounds forming solid solutions.
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