Phenotypic plasticity represents the most relevant hallmark of the carcinoma cell as it
bestows it with the capacity of transiently altering its morphological and functional features
while en route to the metastatic site. However, the study of phenotypic plasticity is hindered
by the rarity of these events within primary lesions and by the lack of experimental models.
Here, we identified a subpopulation of phenotypic plastic colon cancer cells: EpCAMlo cells
are motile, invasive, chemo-resistant, and highly metastatic. EpCAMlo bulk and single-cell …