Phthalocyanine-BODIPY dye: synthesis, characterization, and utilization for pattern recognition of CYFRA 21-1 in whole blood samples
RI Stefan-van Staden, IR Comnea-Stancu… - Analytical and …, 2017 - Springer
Analytical and bioanalytical chemistry, 2017•Springer
Phthalocyanine-BODIPY dye (BODIPY= boron dipyrromethene) was synthesized, fully
characterized, and used for molecular recognition of CYFRA 21-1, a lung cancer biomarker,
from whole blood samples. Thin films of three magnesium oxides ((MgO) n, where n= 8, 9, or
10)) were deposited on a paper substrate, and they were immersed in a solution of
phthalocyanine-BODIPY dye (1.17× 10− 3 mol/L) for the design of stochastic sensors. Limits
of determination of picograms per milliliter magnitude order were recorded for the proposed …
characterized, and used for molecular recognition of CYFRA 21-1, a lung cancer biomarker,
from whole blood samples. Thin films of three magnesium oxides ((MgO) n, where n= 8, 9, or
10)) were deposited on a paper substrate, and they were immersed in a solution of
phthalocyanine-BODIPY dye (1.17× 10− 3 mol/L) for the design of stochastic sensors. Limits
of determination of picograms per milliliter magnitude order were recorded for the proposed …
Abstract
Phthalocyanine-BODIPY dye (BODIPY = boron dipyrromethene) was synthesized, fully characterized, and used for molecular recognition of CYFRA 21-1, a lung cancer biomarker, from whole blood samples. Thin films of three magnesium oxides ((MgO) n , where n = 8, 9, or 10)) were deposited on a paper substrate, and they were immersed in a solution of phthalocyanine-BODIPY dye (1.17 × 10−3 mol/L) for the design of stochastic sensors. Limits of determination of picograms per milliliter magnitude order were recorded for the proposed stochastic sensors. CYFRA 21-1 was reliably identified and determined with recoveries higher than 95% and RSD lower than 1% in whole blood samples.
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