Introduction: The relevance of work is dictated by the fact that arterial hypertension is often associated with other diseases and every physician and senior student should be aware of the contraindications to antihypertensive therapy (AT) in the most common nosologies-aVblock 2nd and 3rd degree, WPW-syndrome, gout, COPD and pregnancy. Aim: To analyze physicians' and medical undergraduates' knowledge of main contraindications to AH treatment. Material and Methods: During the multicenter study devoted to the assessment of physicians' knowledge in treatment of AH (" PHYSTARH" study), 296 people from 5 Russian and Ukrainian cities were surveyed in 2017-2018: 44, 9%-6th grade students, 55, 1%-physicians. Results and Discussion. The study revealed an insufficient level of students' and doctors' knowledge of main contraindications to AH treatment. Less than half of the respondents correctly identified drugs contraindicated in pregnancy, gout, aV-block 2nd and 3rd degree, WPW-syndrome and COPD. Conclusion. Despite the availability of antihypertensive treatment related clinical guidelines and sufficient number of information sources, the level of incorrect answers reaches a significant level in certain nosologies.