Phytochemicals of Barleria cristata and Butea monospermosa as drug targets against Asparaginyl t-RNA synthetase of Brugiya malayi: an insilico approach.
NA Nateshan Anil, AB Aashish Baldwa… - 2012 - cabidigitallibrary.org
Abstract Asparaginyl t-RNA Synthetase (AsnRS) of Brugiya malayi has been exploited as
target for lymphatic filariasis therapeutics. AsnRS is a member of the aminoacyl tRNA
synthetase (AARS) family, a set of structurally heterogenous enzymes, specific for each
amino acid. AsnRS hooks asparagine to tRNA, used during protein synthesis. AARS are
potential drug targets as they are essential for survival and are structurally different between
species. AARS also functions as an immunosuppressant, blocking interleukin 8 receptors in …
target for lymphatic filariasis therapeutics. AsnRS is a member of the aminoacyl tRNA
synthetase (AARS) family, a set of structurally heterogenous enzymes, specific for each
amino acid. AsnRS hooks asparagine to tRNA, used during protein synthesis. AARS are
potential drug targets as they are essential for survival and are structurally different between
species. AARS also functions as an immunosuppressant, blocking interleukin 8 receptors in …
[PDF][PDF] Phytochemicals of Barleria cristata and Butea monospermosa as drug targets against Asparaginyl t-RNA synthetase of Brugiya malayi: Aninsilico approach
N Anil, A Baldwa, S Lalani, K Subramanyam… - Journal of Pharmacy …, 2012 - academia.edu
ABSTRACT Asparaginyl t-RNA Synthetase (AsnRS) of Brugiya malayi has been exploited
as target for lymphatic filariasis therapeutics. AsnRS is a member of the aminoacyl tRNA
synthetase (AARS) family, a set of structurally heterogenous enzymes, specific for each
amino acid. AsnRS hooks asparagine to tRNA, used during protein synthesis. AARS are
potential drug targets as they are essential for survival and are structurally different between
species. AARS also functions as an immunosuppressant, blocking interleukin 8 receptors in …
as target for lymphatic filariasis therapeutics. AsnRS is a member of the aminoacyl tRNA
synthetase (AARS) family, a set of structurally heterogenous enzymes, specific for each
amino acid. AsnRS hooks asparagine to tRNA, used during protein synthesis. AARS are
potential drug targets as they are essential for survival and are structurally different between
species. AARS also functions as an immunosuppressant, blocking interleukin 8 receptors in …
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