Pinostrobin attenuates azoxymethane-induced colorectal cytotoxicity in rats through augmentation of apoptotic Bax/Bcl-2 proteins and antioxidants
B Ali Abed Wahab, N Ain Salehen… - SAGE Open …, 2023 - journals.sagepub.com
Objectives: Pinostrobin (5-hydroxy-7-methoxyflavanone; PN) is a natural active ingredient
with numerous biological activities extensively utilized in tumour chemotherapy. The present
study investigates the chemo-preventive potentials of PN on azoxymethane-mediated
colonic aberrant crypt foci in rats. Methods: Sprague Dawley rats clustered into five groups,
normal control (A) and cancer controls were subcutaneously injected with normal saline and
15 mg/kg azoxymethane, respectively, and nourished on 10% tween 20 and fed on 10 …
with numerous biological activities extensively utilized in tumour chemotherapy. The present
study investigates the chemo-preventive potentials of PN on azoxymethane-mediated
colonic aberrant crypt foci in rats. Methods: Sprague Dawley rats clustered into five groups,
normal control (A) and cancer controls were subcutaneously injected with normal saline and
15 mg/kg azoxymethane, respectively, and nourished on 10% tween 20 and fed on 10 …
[HTML][HTML] Pinostrobin attenuates azoxymethane-induced colorectal cytotoxicity in rats through augmentation of apoptotic Bax/Bcl-2 proteins and antioxidants
BAA Wahab, NA Salehen, MA Abdulla… - SAGE Open …, 2023 - ncbi.nlm.nih.gov
Objectives: Pinostrobin (5-hydroxy-7-methoxyflavanone; PN) is a natural active ingredient
with numerous biological activities extensively utilized in tumour chemotherapy. The present
study investigates the chemo-preventive potentials of PN on azoxymethane-mediated
colonic aberrant crypt foci in rats. Methods: Sprague Dawley rats clustered into five groups,
normal control (A) and cancer controls were subcutaneously injected with normal saline and
15 mg/kg azoxymethane, respectively, and nourished on 10% tween 20 and fed on 10 …
with numerous biological activities extensively utilized in tumour chemotherapy. The present
study investigates the chemo-preventive potentials of PN on azoxymethane-mediated
colonic aberrant crypt foci in rats. Methods: Sprague Dawley rats clustered into five groups,
normal control (A) and cancer controls were subcutaneously injected with normal saline and
15 mg/kg azoxymethane, respectively, and nourished on 10% tween 20 and fed on 10 …
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