Introduction Magnetic resonance imaging-guided transurethral ultrasound ablation (TULSA)
of the prostate uses ultrasound to thermally coagulate tissue under real-time MRI guidance.
Real-time feedback from closed-loop MRI thermometry automatically controls treatment
parameters to match tissue response in the prescribed ablation volume. The pivotal study of
TULSA (“TACT”, NCT02766543), which included a low-to intermediate-risk prostate cancer
(PCa) population, has reached the end of the 5-year follow-up duration. Here we report the …

Abstract INTRODUCTION AND OBJECTIVE: Magnetic resonance imaging-guided
transurethral ultrasound ablation (TULSA) of the prostate is an in-bore procedure that
thermally coagulates tissue under real-time closed-loop MRI thermometry control, allowing
precise adjustment of treatment parameters to match tissue effects. We report4-year
outcomes from the TACT pivotal trial of TULSA in men with low-to intermediate-risk prostate
cancer (PCa)(NCT02766543). METHODS: Across 13 sites in 5 countries, 115 men with …