[HTML][HTML] Plasma concentrations of inflammatory cytokines rise rapidly during ECMO-related SIRS due to the release of preformed stores in the intestine
RB McILwain, JG Timpa, AR Kurundkar, DW Holt… - Laboratory …, 2010 - Elsevier
Extracorporeal membrane oxygenation (ECMO) is a life-saving support system used in
neonates and young children with severe cardiorespiratory failure. Although ECMO has
reduced mortality in these critically ill patients, almost all patients treated with ECMO
develop a systemic inflammatory response syndrome (SIRS) characterized by a 'cytokine
storm', leukocyte activation, and multisystem organ dysfunction. We used a neonatal porcine
model of ECMO to investigate whether rising plasma concentrations of inflammatory …
neonates and young children with severe cardiorespiratory failure. Although ECMO has
reduced mortality in these critically ill patients, almost all patients treated with ECMO
develop a systemic inflammatory response syndrome (SIRS) characterized by a 'cytokine
storm', leukocyte activation, and multisystem organ dysfunction. We used a neonatal porcine
model of ECMO to investigate whether rising plasma concentrations of inflammatory …
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