Plasmid-Mediated mcr-1 Colistin Resistance in Escherichia coli from a Black Kite in Russia
H Tarabai, A Valcek, I Jamborova… - Antimicrobial Agents …, 2019 - Am Soc Microbiol
H Tarabai, A Valcek, I Jamborova, SV Vazhov, IV Karyakin, R Raab, I Literak, M Dolejska
Antimicrobial Agents and Chemotherapy, 2019•Am Soc MicrobiolThe gene mcr-1 conferring resistance to last-line antibiotic colistin has been reported
globally. Here, we describe the first detection of plasmid-mediated colistin resistance in
Russian wildlife, an isolate of Escherichia coli sequence type 2280 from a black kite (Milvus
migrans) scavenging raptor. Whole-genome sequencing and plasmid transferability
experiments revealed that mcr-1.1 was located on conjugative IncI2 plasmid pDR164
(59891 bp). Migratory black kites may contribute to the global spread of mobile colistin …
globally. Here, we describe the first detection of plasmid-mediated colistin resistance in
Russian wildlife, an isolate of Escherichia coli sequence type 2280 from a black kite (Milvus
migrans) scavenging raptor. Whole-genome sequencing and plasmid transferability
experiments revealed that mcr-1.1 was located on conjugative IncI2 plasmid pDR164
(59891 bp). Migratory black kites may contribute to the global spread of mobile colistin …
Abstract
The gene mcr-1 conferring resistance to last-line antibiotic colistin has been reported globally. Here, we describe the first detection of plasmid-mediated colistin resistance in Russian wildlife, an isolate of Escherichia coli sequence type 2280 from a black kite (Milvus migrans) scavenging raptor. Whole-genome sequencing and plasmid transferability experiments revealed that mcr-1.1 was located on conjugative IncI2 plasmid pDR164 (59891 bp). Migratory black kites may contribute to the global spread of mobile colistin resistance.
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