[HTML][HTML] Plasminogen activator inhibitor‐1 and vitronectin expression level and stoichiometry regulate vascular smooth muscle cell migration through physiological …
N Garg, N Goyal, TL Strawn, J Wu, KM Mann… - Journal of Thrombosis …, 2010 - Elsevier
Background: Vascular smooth muscle cell (VSMC) migration is a critical process in arterial
remodeling. Purified plasminogen activator inhibitor‐1 (PAI‐1) is reported to both promote
and inhibit VSMC migration on two‐dimensional (D) surfaces. Objective: To determine the
effects of PAI‐1 and vitronectin (VN) expressed by VSMC themselves on migration through
physiological collagen matrices. Methods: We studied migration of wild‐type (WT), PAI‐1‐
deficient, VN‐deficient, PAI‐1/VN doubly‐deficient (DKO) and PAI‐1‐transgenic (Tg) VSMC …
remodeling. Purified plasminogen activator inhibitor‐1 (PAI‐1) is reported to both promote
and inhibit VSMC migration on two‐dimensional (D) surfaces. Objective: To determine the
effects of PAI‐1 and vitronectin (VN) expressed by VSMC themselves on migration through
physiological collagen matrices. Methods: We studied migration of wild‐type (WT), PAI‐1‐
deficient, VN‐deficient, PAI‐1/VN doubly‐deficient (DKO) and PAI‐1‐transgenic (Tg) VSMC …
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